The purpose of this study was to assess the influence of quality of work-life on job satisfaction in selected public ministries in Kigali city Rwanda. This research emanates from the importance of QWL within public institutions and how it influences the employees’ job satisfaction. The study used a descriptive and correlational research designs. The study was guided by the hypothesis that there is no significant relationship between QWL variables and job satisfaction. There were 203 employees of selected public institutions who participated in the study.  The researcher used means and standard deviation to determine the respondents’ perceptions on their job satisfaction and quality of work-life.  Pearson product-moment correlation coefficient was used to establish the relationship between job satisfaction and quality of work-life.   By using multiple regression analysis, the research demonstrated the best predictor variables of job satisfaction within the researched ministries.
The findings revealed that the employees of public ministries tend to be positive in their perceptions of the quality of work-life in terms of working conditions, workers’ development, social integration/participation, eminence of work life, social relevance and task accomplishment.  Moreover, the workers tend to be satisfied in their job.  The findings revealed also that workers’ development and eminence of work-life are the best predictors of the job satisfaction. The research provided some recommendation about how the public ministries may improve the quality of work-life within workplace.